Baptist Cardiac and Vascular Institute, Miami, Fl, USA.
J Vasc Surg. 2010 Jul;52(1):199-204. doi: 10.1016/j.jvs.2009.12.048. Epub 2010 Mar 28.
Intermittent programmed compression of the chronically ischemic limb is associated with arteriogenesis. However, progenitor cell elements contributing to this neovascularization are typically diminished in number and function in the elderly dysvascular patient, particularly in the presence of diabetes, renal insufficiency, and cardiac disease. Granulocyte-colony stimulation factor (G-CSF) dramatically boosts the circulating progenitor cell count. G-CSF was administered in 2 patients being treated for ischemic wounds with an intermittent programmed pneumatic compression device (PPCD). Both had comorbidities associated with diminished circulating progenitor cell counts. Remarkable clinical, hemodynamic, and angiographic improvement was observed. Further study of this synergistic strategy is warranted.
间歇性程控缺血肢体压缩与动脉生成有关。然而，在老年血管疾病患者中，特别是在存在糖尿病、肾功能不全和心脏病的情况下，参与这种新生血管形成的祖细胞元素数量和功能通常会减少。粒细胞集落刺激因子（G-CSF）可显著增加循环祖细胞计数。在使用间歇性程控气动压缩装置（PPCD）治疗缺血性伤口的 2 名患者中给予了 G-CSF。两者均存在与循环祖细胞计数减少相关的合并症。观察到显著的临床、血流动力学和血管造影改善。需要进一步研究这种协同策略。
