Berti Lorenzo, Burley Glenn A
CNR-INFM, National Research Center on Nanostructures and Biosystems at Surfaces S3, Via Campi, 213/A 41100 Modena, Italy.
Nat Nanotechnol. 2008 Feb;3(2):81-7. doi: 10.1038/nnano.2007.460.
Since the advent of practical methods for achieving DNA metallization, the use of nucleic acids as templates for the synthesis of inorganic nanoparticles (NPs) has become an active area of study. It is now widely recognized that nucleic acids have the ability to control the growth and morphology of inorganic NPs. These biopolymers are particularly appealing as templating agents as their ease of synthesis in conjunction with the possibility of screening nucleotide composition, sequence and length, provides the means to modulate the physico-chemical properties of the resulting NPs. Several synthetic procedures leading to NPs with interesting photophysical properties as well as studies aimed at rationalizing the mechanism of nucleic acid-templated NP synthesis are now being reported. This progress article will outline the current understanding of the nucleic acid-templated process and provides an up to date reference in this nascent field.
自从实现DNA金属化的实用方法出现以来，利用核酸作为无机纳米颗粒（NPs）合成的模板已成为一个活跃的研究领域。现在人们普遍认识到，核酸具有控制无机纳米颗粒生长和形态的能力。这些生物聚合物作为模板剂特别有吸引力，因为它们易于合成，同时有可能筛选核苷酸组成、序列和长度，这为调节所得纳米颗粒的物理化学性质提供了手段。目前正在报道几种合成具有有趣光物理性质的纳米颗粒的方法，以及旨在阐明核酸模板纳米颗粒合成机制的研究。这篇进展文章将概述目前对核酸模板过程的理解，并为这个新兴领域提供最新的参考。
