Maitland Norman J, Collins Anne T
YCR Cancer Research Unit, Deparment of Biology, University of York, York YO10 5YW, United Kingdom.
J Cell Biochem. 2008 Nov 1;105(4):931-9. doi: 10.1002/jcb.21843.
Inflammation has been implicated for some time as a potential aetiological agent in human prostate cancer. Viral and bacterial infections or even chemical carcinogens such as those found in cooked meat have been proposed as the inflammatory stimuli, but the mechanism of cancer induction is unknown. Recent information about gene expression patterns in normal and malignant epithelial stem cells from human prostate provides a new hypothesis for inflammation-induced carcinogenesis. The hypothesis states that in the stem cells located in the basal cell compartment of the prostate, activated prostate epithelial stem cells acquire a survival advantage, by expressing one of more of the same cytokines such as IL6. The establishment of one or more autocrine signalling loops results in an expansion of these cells in the absence of inflammation, as a potential first stage in the development of the tumour.
一段时间以来，炎症一直被认为是人类前列腺癌的一种潜在病因。病毒和细菌感染，甚至像熟肉中发现的化学致癌物都被认为是炎症刺激因素，但癌症诱发机制尚不清楚。最近有关人类前列腺正常和恶性上皮干细胞基因表达模式的信息为炎症诱导致癌作用提供了一个新假说。该假说认为，在前列腺基底细胞区室的干细胞中，活化的前列腺上皮干细胞通过表达一种或多种相同的细胞因子（如白细胞介素6）获得生存优势。一个或多个自分泌信号回路的建立导致这些细胞在无炎症情况下扩增，这可能是肿瘤发展的第一阶段。
