前列腺液微生物群与前列腺癌相关。

The Microbiome of Prostate Fluid Is Associated With Prostate Cancer.

作者信息

Ma Xiaowei, Chi Chenfei, Fan Liancheng, Dong Baijun, Shao Xiaoguang, Xie Shaowei, Li Min, Xue Wei

机构信息

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Front Microbiol. 2019 Jul 19;10:1664. doi: 10.3389/fmicb.2019.01664. eCollection 2019.

OBJECTIVES

To explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients.

PATIENTS AND METHODS

The microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing.

RESULTS

Compared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera , , , , , and , showed a significant difference between the CA group and NCA group.

CONCLUSION

The prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.