萘普生所致的伴有嗜酸性粒细胞增多的肺部浸润

Pulmonary infiltrates with eosinophilia due to naproxen.

作者信息

Ogawa H, Kurashima K, Namura M, Kanaya H, Kawamura Y, Ohka T, Kurumaya H, Yasui M, Fujimura M, Matsuda T

机构信息

Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.

出版信息

Jpn J Med. 1991 Jan-Feb;30(1):32-4. doi: 10.2169/internalmedicine1962.30.32.

DOI:10.2169/internalmedicine1962.30.32

PMID:1865574

Abstract

An increasing number of drugs have been implicated in the etiology of eosinophilic pneumonia characterized by the development of pulmonary infiltrates, and peripheral blood eosinophilia. Naproxen is a commonly used nonsteroidal anti-inflammatory drug which may be added to the growing list of pharmacologic agents associated with infiltrative pulmonary lesions. A case of eosinophilic pneumonia induced by Naproxen is described. The results of TBLB, a lymphocyte stimulation test, and a challenge test supported this diagnosis.

摘要

越来越多的药物被认为与嗜酸性粒细胞性肺炎的病因有关，其特征为肺部浸润和外周血嗜酸性粒细胞增多。萘普生是一种常用的非甾体抗炎药，它可能会被列入与浸润性肺部病变相关的药物清单中。本文描述了一例由萘普生引起的嗜酸性粒细胞性肺炎病例。经支气管肺活检、淋巴细胞刺激试验和激发试验的结果支持了这一诊断。