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乙胺嘧啶-磺胺多辛(Fansidar)诱发嗜酸性粒细胞性肺炎患者的磺胺多辛特异性淋巴细胞转化

Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).

作者信息

Daniel P T, Holzschuh J, Berg P A

机构信息

Department II of Internal Medicine, University of Tübingen, Federal Republic of Germany.

出版信息

Thorax. 1989 Apr;44(4):307-9. doi: 10.1136/thx.44.4.307.

DOI:10.1136/thx.44.4.307
PMID:2763233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC461805/
Abstract

A patient developed eosinophilic peripheral pulmonary infiltrates while receiving malaria prophylaxis with sulfadoxine-pyrimethamine (Fansidar). Withdrawal of Fansidar and treatment with corticosteroids led to rapid recovery. No exacerbation occurred after cessation of corticosteroids. Lymphocyte transformation testing gave a positive result in the presence of sulfadoxine but not pyrimethamine. It is concluded that drug hypersensitivity to sulfadoxine was the cause of the eosinophilic pneumonia in this patient.

摘要

一名患者在接受磺胺多辛-乙胺嘧啶(Fansidar)预防疟疾治疗时出现嗜酸性外周肺浸润。停用Fansidar并使用皮质类固醇治疗后迅速康复。停用皮质类固醇后未出现病情加重。淋巴细胞转化试验在有磺胺多辛存在时呈阳性,但在有乙胺嘧啶存在时呈阴性。结论是,该患者嗜酸性肺炎的病因是对磺胺多辛的药物过敏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1934/461805/b4be463871e7/thorax00280-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1934/461805/b4be463871e7/thorax00280-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1934/461805/b4be463871e7/thorax00280-0072-a.jpg

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1
Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).乙胺嘧啶-磺胺多辛(Fansidar)诱发嗜酸性粒细胞性肺炎患者的磺胺多辛特异性淋巴细胞转化
Thorax. 1989 Apr;44(4):307-9. doi: 10.1136/thx.44.4.307.
2
[Eosinophilic lung infiltration during malaria prophylaxis with pyrimethamine-sulfadoxine (Fansidar)].[使用乙胺嘧啶-磺胺多辛(Fansidar)预防疟疾期间的嗜酸性粒细胞性肺浸润]
Schweiz Med Wochenschr. 1985 Aug 24;115(34):1174-6.
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Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).使用乙胺嘧啶-磺胺多辛(Fansidar)进行短期预防期间出现的异常肺部反应。
Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1876. doi: 10.1136/bmj.288.6434.1876.
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Fansidar hypersensitivity pneumonitis.Fansidar诱发的过敏性肺炎。
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Fansidar for malaria prophylaxis.用于疟疾预防的 Fansidar(复方磺胺多辛-乙胺嘧啶片)
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Adverse reactions to Fansidar and updated recommendations for its use in the prevention of malaria. Fansidar的不良反应及其预防疟疾使用的最新建议。
MMWR Morb Mortal Wkly Rep. 1985 Jan 4;33(51-52):713-4.
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[Acute hepatitis following administration of fansidar].[服用 Fansidar 后出现的急性肝炎]
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[Stevens-Johnson syndrome and granulopenia induced by sulfadoxine-pyrimethamine (Fansidar)].[磺胺多辛-乙胺嘧啶(Fansidar)诱发的史蒂文斯-约翰逊综合征和粒细胞减少症]
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[Malaria prevention with Fansidar as a cause of Stevens-Johnson syndrome].[使用 Fansidar 预防疟疾导致史蒂文斯-约翰逊综合征]
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本文引用的文献

1
Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).使用乙胺嘧啶-磺胺多辛(Fansidar)进行短期预防期间出现的异常肺部反应。
Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1876. doi: 10.1136/bmj.288.6434.1876.
2
Eosinophil-mediated injury to lung parenchymal cells and interstitial matrix. A possible role for eosinophils in chronic inflammatory disorders of the lower respiratory tract.嗜酸性粒细胞介导的对肺实质细胞和间质基质的损伤。嗜酸性粒细胞在下呼吸道慢性炎症性疾病中的可能作用。
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The eosinophilic pneumonias.
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[Eosinophilic lung infiltration during malaria prophylaxis with pyrimethamine-sulfadoxine (Fansidar)].[使用乙胺嘧啶-磺胺多辛(Fansidar)预防疟疾期间的嗜酸性粒细胞性肺浸润]
Schweiz Med Wochenschr. 1985 Aug 24;115(34):1174-6.
5
Fansidar hypersensitivity pneumonitis.Fansidar诱发的过敏性肺炎。
Br J Dis Chest. 1987 Apr;81(2):194-6. doi: 10.1016/0007-0971(87)90140-9.
6
Co-trimoxazole-induced hepatic injury--an analysis of cases with hypersensitivity-like reactions.复方新诺明所致肝损伤——对类似过敏反应病例的分析
Infection. 1987;15 Suppl 5:S259-64. doi: 10.1007/BF01643200.
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[Drug hypersensitivity. Diagnosis and immunopathogenesis].[药物超敏反应。诊断与免疫发病机制]
Dtsch Med Wochenschr. 1987 Jan 15;113(2):65-73.
8
The specificity of the lymphocyte transformation test in a patient with hypersensitivity reactions to pyrazolone compounds. A 10-week follow-up study before and after rechallenge.对吡唑酮化合物过敏反应患者淋巴细胞转化试验的特异性。激发前后为期10周的随访研究。
Eur J Clin Pharmacol. 1988;35(1):39-45. doi: 10.1007/BF00555505.
9
Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells.白细胞介素1、白细胞介素3和白细胞介素5在原始造血干细胞产生嗜酸性粒细胞过程中的协同作用。
J Immunol. 1988 Jan 1;140(1):94-9.
10
Indoprofen-induced aplastic anaemia in systemic lupus, diagnosed by lymphocyte transformation tests.通过淋巴细胞转化试验诊断的吲哚美辛诱发的系统性红斑狼疮性再生障碍性贫血。
Lancet. 1985 Jun 22;1(8443):1450-1. doi: 10.1016/s0140-6736(85)91880-x.