Focosi Daniele, Maggi Fabrizio, Pistolesi Donatella, Benedetti Edoardo, Papineschi Federico, Galimberti Sara, Ceccherini-Nelli Luca, Petrini Mario
Division of Hematology, Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Italy.
Leuk Res. 2009 Apr;33(4):556-60. doi: 10.1016/j.leukres.2008.06.018. Epub 2008 Jul 25.
Hemorrhagic cystitis is a common complication in hematopoietic stem cell transplant recipients. We report here a case of severe BKV-associated hemorrhagic cystitis who did not respond to intravenous cidofovir. Overt hematuria successfully resolved after a few days on hyperbaric oxygen and intravesical instillations of cidofovir, while BK viruria dropped after a few weeks and remained low. We review the literature for therapeutic options in hemorrhagic cystitis and try to explain how hyperbaric oxygen stimulates mucosal repair in the urinary bladder.
出血性膀胱炎是造血干细胞移植受者的常见并发症。我们在此报告一例严重的BK病毒相关性出血性膀胱炎病例，该患者对静脉注射西多福韦无反应。在接受高压氧治疗和膀胱内灌注西多福韦几天后，肉眼血尿成功消退，而BK病毒尿症在几周后下降并维持在低水平。我们回顾了出血性膀胱炎治疗选择的文献，并试图解释高压氧如何刺激膀胱黏膜修复。
