Bridges Benjamin, Donegan Sarah, Badros Ashraf
University of Maryland, Baltimore, 21201, USA.
Am J Hematol. 2006 Jul;81(7):535-7. doi: 10.1002/ajh.20567.
We report a case of severe hemorrhagic cystitis after allogeneic transplantation in association with high BK viral load. After failure of aggressive hydration, platelet and blood transfusions, continuous bladder irrigation, and tapering of the immune suppression, we instilled cidofovir into the bladder, which resulted in decreased BK viral load and significant clinical improvement. Our case suggests that local cidofovir therapy for viral hemorrhagic cystitis is effective and well tolerated with no observed side effects.
我们报告了1例异基因移植后出现严重出血性膀胱炎并伴有高BK病毒载量的病例。在积极补液、输注血小板和血液、持续膀胱冲洗以及逐渐减少免疫抑制治疗均失败后，我们将西多福韦注入膀胱，这导致BK病毒载量下降且临床症状显著改善。我们的病例表明，局部应用西多福韦治疗病毒性出血性膀胱炎有效且耐受性良好，未观察到副作用。
