Gastaldello René, Iñiguez Alena Mayo, Otsuki Koko, Lamas Gabriela, Balangero Marcos, Barbas María Gabriela, Mangano Andrea, Sen Luisa, Maturano Eduardo, Remondegui Carlos, Vicente Ana Carolina Paulo, Gallego Sandra
Laboratory of Human Lymphotropic Viruses, Institute of Virology, School of Medicine, Universidad Nacional de Córdoba, Córdoba, Argentina.
AIDS Res Hum Retroviruses. 2008 Sep;24(9):1139-46. doi: 10.1089/aid.2007.0299.
The province of San Salvador de Jujuy, located in the northwest of Argentina, is a highly endemic area for HTLV-1 infection and a foci of tropical spastic paraparesis/HTLV-1-associated myelopathy (HAM/TSP). Therefore, to better understand this, we carried out a genetic characterization of a large set of HTLV-1 strains (n = 65) of descendants of Amerindians from this region. The LTR and env regions were analyzed. The genetic analysis showed that all of these new HTLV-1 isolates from Argentina belong to the Transcontinental subgroup A of the HTLV-1a Cosmopolitan subtype, with the exception of three isolates that cluster within the Japanese subgroup B. Interestingly, the majority of the sequences from Jujuy province belonged to a distinct cluster within the Latin America Transcontinental subgroup, referred to here as the Jujuy subcluster, and were characterized by specific signatures in the LTR. Given that the samples analyzed in this study belong to the Amerindian population and the high prevalence of HTLV-1 in Jujuy in contrast to the low prevalence of this virus in the country, it could be that HTLV-1aA was spread in Argentina from the Amerindians to the cosmopolitan population. Moreover, this is the first report of an HTLV-1aB or Japanese subgroup in descendants of non-Japanese people in South America.
胡胡伊省位于阿根廷西北部，是HTLV - 1感染的高度流行地区以及热带痉挛性截瘫/HTLV - 1相关脊髓病（HAM/TSP）的病灶区。因此，为了更好地了解这一情况，我们对该地区大量美洲印第安人后裔的HTLV - 1毒株（n = 65）进行了基因特征分析。分析了LTR和env区域。基因分析表明，除了三个聚集在日本B亚群内的分离株外，所有来自阿根廷的这些新的HTLV - 1分离株都属于HTLV - 1a世界主义亚型的跨大陆A亚群。有趣的是，胡胡伊省的大多数序列属于拉丁美洲跨大陆亚群内的一个独特簇，在此称为胡胡伊亚簇，并在LTR中具有特定特征。鉴于本研究中分析的样本属于美洲印第安人群体，且与该国该病毒的低流行率相比，胡胡伊省HTLV - 1的高流行率，可能是HTLV - 1aA在阿根廷从美洲印第安人传播到了世界主义人群中。此外，这是南美洲非日本裔人群后裔中HTLV - 1aB或日本亚群的首次报告。
