Berger P, Hillman M, Tabak M, Vollrath M
Hals-Nasen-Ohrenklinik, Medizinische Hochschule Hannover, Germany.
Laryngoscope. 1991 Aug;101(8):895-9. doi: 10.1288/00005537-199108000-00015.
Immunological disorders of the cellular type can be diagnosed by the lymphocyte transformation test (LTT). An autoimmune mechanism of certain cases of sensorineural hearing loss (SNHL) can be evaluated by using human inner ear tissue as an antigen. Recent studies have shown that type II collagen plays an important role, not only in some autoimmune mediated rheumatoid diseases, but also as an antigenic substrate of inner ear tissue in autoimmune sensorineural hearing loss. This paper deals with results of the lymphocyte transformation test using type II collagen as antigen in 68 patients with progressive sensorineural hearing loss (PSNHL) and 68 healthy volunteers. Thirty-four patients showed a strong stimulation in the lymphocyte transformation test, in contrast to only four volunteers in the control group, two of whom had a history of rheumatoid arthritis.
细胞型免疫紊乱可通过淋巴细胞转化试验（LTT）来诊断。某些感音神经性听力损失（SNHL）病例的自身免疫机制可通过将人内耳组织用作抗原来评估。最近的研究表明，II型胶原不仅在一些自身免疫介导的类风湿性疾病中起重要作用，而且在自身免疫性感音神经性听力损失中作为内耳组织的抗原底物。本文探讨了以II型胶原为抗原，对68例进行性感音神经性听力损失（PSNHL）患者和68名健康志愿者进行淋巴细胞转化试验的结果。34例患者在淋巴细胞转化试验中表现出强烈刺激，相比之下，对照组中只有4名志愿者有此表现，其中2名有类风湿性关节炎病史。
