Trott M S, Hughes G B, Calabrese L H, Barna B P, Nodar R H
Cleveland Clinic Foundation, Department of Otolaryngology and Communicative Disorders, Ohio, USA.
Ear Nose Throat J. 1996 Oct;75(10):666-8.
Immune sensorineural hearing loss is manifested in several systemic immune diseases. Although hearing loss has been previously documented in patients with Sjögren's syndrome (SS), the effect of SS on hearing is unclear. This prospective study was designed to assess the presence of hearing loss in 14 patients with SS and, if sensorineural hearing loss was present, to determine if the hearing loss was immune-mediated. Patients were evaluated with basic audiologic tests as well as for cellular immune inner ear reactivity as measured by the lymphocyte transformation test (LTT). Three patients had evidence of sensorineural hearing loss. Two patients had a positive LTT without evidence of sensorineural hearing loss. This preliminary study suggests that SS may not directly cause sensorineural hearing loss, immuno-mediated or otherwise.
免疫性感音神经性听力损失在多种全身性免疫疾病中均有表现。尽管此前已有干燥综合征（SS）患者出现听力损失的记录，但SS对听力的影响尚不清楚。本前瞻性研究旨在评估14例SS患者中听力损失的情况，若存在感音神经性听力损失，则确定其是否为免疫介导。对患者进行了基本听力测试以及通过淋巴细胞转化试验（LTT）测量的细胞免疫内耳反应性评估。3例患者有感音神经性听力损失的证据。2例患者LTT呈阳性，但无感音神经性听力损失的证据。这项初步研究表明，SS可能不会直接导致感音神经性听力损失，无论是否为免疫介导。
