Bianchi Alessandro, Shore David
Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Geneva, Switzerland.
Mol Cell. 2008 Jul 25;31(2):153-65. doi: 10.1016/j.molcel.2008.06.013.
The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerase-promoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.
端粒酶可合成端粒DNA重复序列，它在顺式作用下由端粒蛋白/DNA复合物在单个染色体末端进行调控，这种调控方式依赖于端粒重复序列阵列的长度。结合在双链DNA重复序列上的端粒酶抑制因子和结合在单链末端DNA悬垂上的端粒酶促进因子之间的动态相互作用，似乎可调节端粒酶活性，并与端粒的瞬时去保护直接相关。我们讨论了酵母和哺乳动物系统中染色体末端端粒酶调控机制的最新进展。
