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来自西部菱斑响尾蛇的血管凋亡诱导蛋白VAP1和VAP2的出血活性。

Hemorrhagic activity of the vascular apoptosis-inducing proteins VAP1 and VAP2 from Crotalus atrox.

作者信息

Kikushima Eiichi, Nakamura Shiho, Oshima Yasunori, Shibuya Tomoko, Miao Jun Ying, Hayashi Hiroshi, Nikai Toshiaki, Araki Satohiko

机构信息

Marine Biological Laboratory, Graduate School of Science, Nagoya University, Sugashima-cho 429-63, Toba, Mie 517-0004, Japan.

出版信息

Toxicon. 2008 Sep 15;52(4):589-93. doi: 10.1016/j.toxicon.2008.06.027. Epub 2008 Jul 9.

DOI:10.1016/j.toxicon.2008.06.027
PMID:18657564
Abstract

Vascular apoptosis-inducing proteins (VAPs) from hemorrhagic snake venom are apoptosis-inducing toxins that target vascular endothelial cells. We now show that VAP1 and VAP2 from Crotalus atrox have hemorrhagic activity in mouse skin following intradermal injection. Following intravenous injection, VAP2 induced hemorrhage in the lung, intestine and kidney. Although the hemorrhagic activity was relatively weak, these apoptosis toxins may play a role in the complex mechanism of snake venom-induced hemorrhage.

摘要

来自出血性蛇毒的血管凋亡诱导蛋白（VAPs）是靶向血管内皮细胞的凋亡诱导毒素。我们现在表明，来自西部菱斑响尾蛇的VAP1和VAP2在皮内注射后在小鼠皮肤中具有出血活性。静脉注射后，VAP2在肺、肠和肾中诱导出血。尽管出血活性相对较弱，但这些凋亡毒素可能在蛇毒诱导出血的复杂机制中起作用。

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