Sharma Deepika, Narasimhan Balasubramanian, Kumar Pradeep, Jalbout Abraham
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.
Eur J Med Chem. 2009 Mar;44(3):1119-27. doi: 10.1016/j.ejmech.2008.06.009. Epub 2008 Jun 24.
A series of 2-(substituted phenyl)-1H-benzimidazole (1-10) and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (11-19) derivatives were synthesized and tested in vitro for their antimicrobial activity. The results of QSAR investigation indicated the importance of molecular descriptors, dipole moment (mu), log of octanol water partition coefficient (logP) and second order molecular connectivity index ((2)chi) in describing the antimicrobial activity of the synthesized compounds.
合成了一系列2-（取代苯基）-1H-苯并咪唑（1-10）和[2-（取代苯基）-苯并咪唑-1-基]-吡啶-3-基-甲酮（11-19）衍生物，并对其进行了体外抗菌活性测试。定量构效关系（QSAR）研究结果表明，分子描述符、偶极矩（μ）、正辛醇-水分配系数的对数（logP）和二阶分子连接性指数（（2）χ）在描述合成化合物的抗菌活性方面具有重要意义。
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