Bujor Alexandru, Hanganu Anamaria, Tecuceanu Victorita, Madalan Augustin M, Tudose Madalina, Marutescu Luminita, Popa Marcela, Chifiriuc Carmen Mariana, Zarafu Irina, Ionita Petre
Faculty of Chemistry, University of Bucharest, 90 Panduri, 050663 Bucharest, Romania.
'C. D. Nenitzescu' Institute of Organic and Supramolecular Chemistry of the Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, Romania.
Antioxidants (Basel). 2023 Mar 13;12(3):713. doi: 10.3390/antiox12030713.
4-Aminodiphenylamino derivatives were investigated for their antioxidant and hydrophobicity character, together with other biological measurements, such as antimicrobial and antibiofilm activity. Among these nine compounds used, we obtained novel derivatives via reaction of the starting material with NBD-chloride. Therefore, we performed a full structural analysis for these compounds, i.e., elemental analysis, IR, UV-Vis, H- and C-NMR, ESI-MS, X-ray diffraction on single crystal, etc. The hydrophobicity of all the compounds was measured either experimentally using the RP-TLC technique, or via calculation using the fragments method. The other structural characteristics were analyzed, and a correlation between the experimental and computed properties was found. Moreover, the results of the biological evaluation showed that some of the synthesized compounds have antimicrobial and antibiofilm activity.
对4-氨基二苯胺衍生物进行了抗氧化和疏水性研究，并进行了其他生物学测定，如抗菌和抗生物膜活性。在使用的这九种化合物中，我们通过起始原料与NBD-氯化物反应获得了新型衍生物。因此，我们对这些化合物进行了全面的结构分析，即元素分析、红外光谱、紫外可见光谱、氢和碳核磁共振、电喷雾质谱、单晶X射线衍射等。所有化合物的疏水性要么通过RP-TLC技术进行实验测量，要么通过片段法进行计算。分析了其他结构特征，并发现了实验性质和计算性质之间的相关性。此外，生物学评价结果表明，一些合成化合物具有抗菌和抗生物膜活性。
