Nguyen Nam P, Garland Linda, Welsh James, Hamilton Russ, Cohen Deirdre, Vinh-Hung Vincent
Department of Radiation Oncology, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ, USA.
Cancer Treat Rev. 2008 Dec;34(8):719-27. doi: 10.1016/j.ctrv.2008.06.001. Epub 2008 Jul 26.
Management of early stages non-small cell lung carcinoma has traditionally been surgery with radiation selected for medically inoperable patients. Recent emergence of stereotactic body radiation therapy allows for delivery of high radiation dose to the tumor while sparing normal lungs. This reviews compares loco-regional control, survival and complications rates between these two treatment modalities. Literature search identifies studies with stereotactic body radiation therapy and surgery for early stages non-small cell lung cancer. Effectiveness and toxicity of these two modalities was assessed. Stereotactic body radiation therapy is associated with minimal morbidity and provides comparable local control and survival in patients with multiple co-morbidities factors. Stereotactic body radiation therapy may become standard of care for operable early stages non-small cell lung cancer.
早期非小细胞肺癌的治疗传统上是手术，对于医学上无法手术的患者则选择放疗。立体定向体部放疗的出现使得在保护正常肺组织的同时能够向肿瘤输送高剂量辐射。本综述比较了这两种治疗方式在局部区域控制、生存率和并发症发生率方面的差异。文献检索确定了有关早期非小细胞肺癌立体定向体部放疗和手术的研究。评估了这两种方式的有效性和毒性。立体定向体部放疗的发病率极低，在有多种合并症因素的患者中能提供相当的局部控制和生存率。立体定向体部放疗可能会成为可手术的早期非小细胞肺癌的标准治疗方法。
