整合素：开启血管生成的关键

Integrins: the keys to unlocking angiogenesis.

作者信息

Silva Rita, D'Amico Gabriela, Hodivala-Dilke Kairbaan M, Reynolds Louise E

机构信息

Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts &The London & Queen Mary's School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London UK.

出版信息

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1703-13. doi: 10.1161/ATVBAHA.108.172015. Epub 2008 Jul 24.

DOI:10.1161/ATVBAHA.108.172015

PMID:18658045

Abstract

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.

摘要

血管生成是指从已有的脉管系统形成新的血管，它在包括缺血性疾病和癌症在内的许多疾病的发病机制中发挥作用。整合素是在内皮细胞和周细胞表面表达的细胞粘附分子，使其成为抗血管生成治疗的潜在靶点。在此，我们综述内皮细胞和壁细胞整合素对血管生成的作用，并强调它们作为抗血管生成靶点的潜力。