Tilly-Kiesi M
Third Department of Medicine, University of Helsinki, Finland.
Metabolism. 1991 Jun;40(6):623-8. doi: 10.1016/0026-0495(91)90054-z.
The effects of lovastatin treatment on density distribution and composition of low-density lipoproteins (LDL) were studied using a density gradient ultracentrifugation method in 35 hypercholesterolemic patients with severe peripheral vascular disease. Lovastatin caused a 32% mean reduction in LDL particle mass and a 36% reduction in LDL cholesterol. The cholesteryl ester to apolipoprotein (apo) B, free cholesterol to apo B, and phospholipid to apo B weight ratios in LDL decreased significantly during treatment (P less than .01, P less than .01, and P less than .001, respectively). The effect on plasma triglycerides (Tg) was not uniform. Plasma Tg levels decreased in 25 patients, but increased in 10 patients. Since plasma Tg level influences the LDL density distribution and composition, the patients were also subgrouped and analyzed according to change in plasma Tg. In those with increased plasma Tg, the light LDL particles were reduced more and the dense particles less compared with patients with decreased Tg. The mean Tg content of LDL increased (from 7.7% to 9.3%; P less than .05) and the weight ratio of core lipids (cholesteryl ester/Tg) in LDL decreased (from 4.57 to 3.44; P less than .01) in patients with increased plasma Tg during treatment. The results indicate that the change in plasma Tg (decrease or increase) determined the qualitative changes in LDL observed during lovastatin treatment.
采用密度梯度超速离心法，对35例患有严重外周血管疾病的高胆固醇血症患者进行研究，以探讨洛伐他汀治疗对低密度脂蛋白（LDL）密度分布和组成的影响。洛伐他汀使LDL颗粒质量平均降低32%，LDL胆固醇降低36%。治疗期间，LDL中胆固醇酯与载脂蛋白（apo）B的重量比、游离胆固醇与apo B的重量比以及磷脂与apo B的重量比均显著降低（分别为P<0.01、P<0.01和P<0.001）。对血浆甘油三酯（Tg）的影响并不一致。25例患者的血浆Tg水平降低，但10例患者升高。由于血浆Tg水平会影响LDL的密度分布和组成，因此还根据血浆Tg的变化对患者进行了分组和分析。与血浆Tg降低患者相比，血浆Tg升高患者中轻LDL颗粒减少更多，而重颗粒减少较少。治疗期间血浆Tg升高的患者，LDL的平均Tg含量增加（从7.7%增至9.3%；P<0.05），LDL中核心脂质（胆固醇酯/Tg）的重量比降低（从4.57降至3.44；P<0.01）。结果表明，血浆Tg的变化（降低或升高）决定了洛伐他汀治疗期间观察到的LDL的定性变化。
