Dijk S, Krugers H J, Korf J
Department of Biological Psychiatry, Psychiatric University Clinic, Groningen, The Netherlands.
Neuropharmacology. 1991 May;30(5):469-73. doi: 10.1016/0028-3908(91)90008-y.
Whether inducing catalepsy in the rat by an intraperitoneal injection of haloperidol (0.5 mg/kg) had an effect on metabolism in the striatum and in the hippocampus, as determined by lactography, and whether reducing the cataleptic state with stress or theophylline (8 mg/kg i.v.) had any impact on metabolism in these two regions of the brain was investigated. Furthermore, whether theophylline reduced catalepsy in rats through the adrenals was investigated. Haloperidol caused a significant increase in the metabolism of lactate, both in the striatum and in the hippocampus. Reducing haloperidol-induced catalepsy with short-term immobilisation stress did not affect the metabolism of lactate, neither in the striatum nor in the hippocampus. Reducing haloperidol-induced catalepsy with theophylline caused a significant rise in the metabolism of lactate in the striatum, while no effect was seen in the hippocampus. Adrenalectomy did not compromise the anti-cataleptic property of theophylline. It is concluded theophylline is a potent antagonist of haloperidol-induced catalepsy, and that this effect is not mediated by the adrenals. Furthermore, it is reported that haloperidol influenced metabolism in regions of the brain not considered to be its primary target. Lactography is considered to be a very useful tool in the study of metabolism during activity.
研究了腹腔注射氟哌啶醇（0.5毫克/千克）诱导大鼠僵住症是否会对纹状体和海马体的代谢产生影响（通过乳酸成像法测定），以及通过应激或静脉注射氨茶碱（8毫克/千克）减轻僵住症状态是否会对这两个脑区的代谢产生任何影响。此外，还研究了氨茶碱是否通过肾上腺减轻大鼠的僵住症。氟哌啶醇导致纹状体和海马体中乳酸代谢显著增加。用短期固定应激减轻氟哌啶醇诱导的僵住症对纹状体和海马体中的乳酸代谢均无影响。用氨茶碱减轻氟哌啶醇诱导的僵住症导致纹状体中乳酸代谢显著升高，而在海马体中未见影响。肾上腺切除术并未损害氨茶碱的抗僵住症特性。得出的结论是，氨茶碱是氟哌啶醇诱导的僵住症的有效拮抗剂，且这种作用不是由肾上腺介导的。此外，据报道氟哌啶醇会影响并非其主要靶点的脑区的代谢。乳酸成像法被认为是研究活动期间代谢的非常有用的工具。
