Casas M, Ferre S, Guix T, Jane F
Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau, (Medical School, U.A.B.), Barcelona, Spain.
Biol Psychiatry. 1988 Oct;24(6):642-8. doi: 10.1016/0006-3223(88)90138-2.
The effect of theophylline (5, 15, or 30 mg/kg sc) on the catalepsy induced by haloperidol in the rat was studied. Theophylline was shown to induce a dose-dependent inhibition of this catalepsy. These data support the hypothesis that the methylxanthines are dopamine agonists and suggest that coffee, tea, and cola drinks should be avoided by patients undergoing neuroleptic treatment.
研究了氨茶碱（5、15或30毫克/千克，皮下注射）对大鼠中由氟哌啶醇诱导的僵住症的影响。结果表明，氨茶碱可诱导对这种僵住症的剂量依赖性抑制。这些数据支持甲基黄嘌呤是多巴胺激动剂的假说，并表明接受抗精神病药物治疗的患者应避免饮用咖啡、茶和可乐饮料。
