Y'-Ty1 cDNA的整合使酿酒酵母端粒酶阴性突变体中的端粒不稳定。
Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants.
作者信息
Maxwell Patrick H, Curcio M Joan
机构信息
Laboratory of Developmental Genetics, Wadsworth Center and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York 12201-2002, USA.
出版信息
Genetics. 2008 Aug;179(4):2313-7. doi: 10.1534/genetics.108.089052. Epub 2008 Jul 27.
Abstract
Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.
摘要
酿酒酵母中的Ty1逆转座子可被端粒侵蚀激活。来自亚端粒Y'重复序列的mRNA的Ty1依赖性逆转录产生嵌合的Y'-Ty1 cDNA。在此，我们表明，在没有端粒酶的情况下，Y'-Ty1 cDNA会整合到正在侵蚀的端粒中。Y'-Ty1 cDNA的端粒整合会促进基因组重排。
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2
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Nature. 2007 Mar 8;446(7132):208-12. doi: 10.1038/nature05560.
3
Methods for determining spontaneous mutation rates.测定自发突变率的方法。
Methods Enzymol. 2006;409:195-213. doi: 10.1016/S0076-6879(05)09012-9.
4
Telomeres, chromosome instability and cancer.端粒、染色体不稳定与癌症。
Nucleic Acids Res. 2006 May 8;34(8):2408-17. doi: 10.1093/nar/gkl303. Print 2006.
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