Fiore Marco, Di Fausto Veronica, Iannitelli Angela, Aloe Luigi
Istituto di Neurobiologia e Medicina Molecolare, Sezione NGF, Consiglio Nazionale delle Ricerche, Rome, Italy.
Ann Ist Super Sanita. 2008;44(2):167-77.
Rats exposed during prenatal life to methylazoxymethanol (MAM) display in postnatal age structural and behavioral deficits resembling those observed in schizophrenic patients. These deficits are associated with significant changes in brain nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), particularly in the hippocampus and entorhinal cortex. In the present study, we used the MAM model to investigate in young rats the effect of antipsychotics, Clozapine and Haloperidol, on brain and blood NGF and BDNF presence. Young animals were used because administration of antipsychotics during adolescence is a common feature of intervention. The results showed that administration of Clozapine and Haloperidol causes significant changes in the concentration of NGF and BDNF in the brain and bloodstream of MAM-treated rats. These findings indicate that these drugs may affect the synthesis and release of neurotrophins in the central nervous system and in the blood circulation. In addition, the MAM model can be a useful tool to investigate the biochemical and molecular mechanisms regarding the effects of antipsychotics.
产前暴露于甲基偶氮甲醇（MAM）的大鼠在出生后会出现结构和行为缺陷，类似于精神分裂症患者所观察到的情况。这些缺陷与脑神经生长因子（NGF）和脑源性神经营养因子（BDNF）的显著变化有关，尤其是在海马体和内嗅皮质。在本研究中，我们使用MAM模型来研究抗精神病药物氯氮平和氟哌啶醇对幼鼠大脑和血液中NGF和BDNF水平的影响。使用幼龄动物是因为在青春期使用抗精神病药物是干预的常见特征。结果表明，氯氮平和氟哌啶醇的给药导致MAM处理大鼠大脑和血液中NGF和BDNF浓度发生显著变化。这些发现表明，这些药物可能会影响中枢神经系统和血液循环中神经营养因子的合成和释放。此外，MAM模型可以成为研究抗精神病药物作用的生化和分子机制的有用工具。
