Fiore M, Korf J, Angelucci F, Talamini L, Aloe L
Institute of Neurobiology, CNR, viale Marx, 43/15, 00137, Rome, Italy.
Physiol Behav. 2000;71(1-2):57-67. doi: 10.1016/s0031-9384(00)00310-3.
We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.
我们在妊娠第11天或12天对怀孕大鼠单次注射乙酸甲基偶氮甲醇（MAM），以研究早期内嗅皮质（EC）和海马发育异常对行为、脑神经生长因子（NGF）和脑源性神经营养因子（BDNF）水平以及神经营养因子受体p75和胆碱乙酰转移酶（ChAT）免疫反应性的长期影响。用MAM处理的成年动物的EC发育受损，并表现出运动和移位活动的变化。此外，与对照大鼠相比，在妊娠第12天接受处理的大鼠的EC和海马中NGF和BDNF的浓度增加。产前给予MAM对EC和隔区中p75和ChAT的分布没有显著影响。本文参照精神疾病的神经发育假说对结果进行了讨论。
