Hooper P L, Kaplan H J
Department of Ophthalmology, University of Western Ontario, London, Canada.
Ophthalmology. 1991 Jun;98(6):944-51; discussion 951-2. doi: 10.1016/s0161-6420(91)32198-5.
Serpiginous choroidopathy is a progressive choroidal inflammatory disorder that typically has a variable saltatory course. Response to steroids is uncertain. By using azathioprine, cyclosporine, and prednisone in combination, the authors have observed rapid remission of active disease in five patients. Remissions have been maintained for periods up to 18 months. Because of the synergistic effects of this combination, doses could rapidly be reduced to maintenance levels without reactivation. Disease in two patients recurred immediately after discontinuation of low-dose therapy but was arrested when therapy resumed. Triple agent immunosuppressive therapy is well tolerated and appears to be effective.
匐行性脉络膜病变是一种进行性脉络膜炎症性疾病，通常病程呈可变的跳跃性。对类固醇的反应尚不确定。通过联合使用硫唑嘌呤、环孢素和泼尼松，作者观察到5例患者的活动性疾病迅速缓解。缓解状态已维持长达18个月。由于这种联合用药的协同作用，剂量可迅速降至维持水平而不会复发。两名患者在低剂量治疗中断后疾病立即复发，但恢复治疗后病情得到控制。三联免疫抑制治疗耐受性良好且似乎有效。
