Baslé Olivier, Li Chao-Jun
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
Org Lett. 2008 Sep 4;10(17):3661-3. doi: 10.1021/ol8012588. Epub 2008 Jul 29.
An efficient method was developed for arylation of sp(3) C-H bonds using copper bromide as catalyst in absence of directing group with arylboronic acids. The oxidative arylation provides easy access to biologically active tetrahydroisoquinoline derivatives and can either use peroxide or molecular oxygen as oxidant.
开发了一种有效的方法，在没有导向基团的情况下，使用溴化铜作为催化剂，以芳基硼酸对sp(3) C-H键进行芳基化反应。该氧化芳基化反应能够方便地合成具有生物活性的四氢异喹啉衍生物，并且既可以使用过氧化物也可以使用分子氧作为氧化剂。
