Suppr超能文献

在相互竞争的心血管、跌倒损伤和药物相关症状结果中,健康结局的优先事项。

Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes.

作者信息

Tinetti Mary E, McAvay Gail J, Fried Terri R, Allore Heather G, Salmon Joanna C, Foody Joanne M, Bianco Luann, Ginter Sandra, Fraenkel Liana

机构信息

Department of Internal Medicine and Epidemiology, New Haven, Connecticut 06504, USA.

出版信息

J Am Geriatr Soc. 2008 Aug;56(8):1409-16. doi: 10.1111/j.1532-5415.2008.01815.x. Epub 2008 Jul 24.

Abstract

OBJECTIVES

To determine the priority that older adults with coexisting hypertension and fall risk give to optimizing cardiovascular outcomes versus fall- and medication symptom-related outcomes.

DESIGN

Interview.

SETTING

Community.

PARTICIPANTS

One hundred twenty-three cognitively intact persons aged 70 and older with hypertension and fall risk.

MEASUREMENTS

Discrete choice task was used to elicit the relative importance placed on reducing the risk of three outcomes: cardiovascular events, serious fall injuries, and medication symptoms. Risk estimates with and without antihypertensive medications were obtained from the literature. Participants chose between 11 pairs of options that displayed lower risks for one or two outcomes and a higher risk for the other outcome(s), versus the reverse. Results were used to calculate relative importance scores for the three outcomes. These scores, which sum to 100, reflect the relative priority participants placed on the difference between the risk estimates of each outcome.

RESULTS

Sixty-two participants (50.4%) placed greater importance on reducing risk of cardiovascular events than reducing risk of the combination of fall injuries and medication symptoms; 61 participants did the converse. A lower percentage of participants with chronic obstructive pulmonary disease (P=.02), unsteadiness (P=.02), functional dependency (P=.04), lower cognition (P=.02) and depressive symptoms (P=.03) prioritized cardiovascular outcomes over fall injuries and medication symptoms than did participants without these characteristics.

CONCLUSION

Interindividual variability in the face of competing outcomes supports individualizing decision-making to individual priorities. In the current example, this may mean forgoing antihypertensive medications or compromising on blood pressure reduction for some individuals.

摘要

目的

确定同时患有高血压和跌倒风险的老年人在优化心血管结局与跌倒及药物症状相关结局方面的优先选择。

设计

访谈。

地点

社区。

参与者

123名70岁及以上认知功能完好、患有高血压且有跌倒风险的人。

测量

采用离散选择任务来引出对降低三种结局风险的相对重视程度:心血管事件、严重跌倒损伤和药物症状。有或没有抗高血压药物的风险估计值来自文献。参与者在11对选项中进行选择,这些选项显示出一种或两种结局风险较低而另一种或几种结局风险较高,反之亦然。结果用于计算三种结局的相对重要性得分。这些得分总和为100,反映了参与者对每种结局风险估计差异所赋予的相对优先级。

结果

62名参与者(50.4%)认为降低心血管事件风险比降低跌倒损伤和药物症状综合风险更重要;61名参与者则相反。与没有这些特征的参与者相比,患有慢性阻塞性肺疾病(P = 0.02)、步态不稳(P = 0.02)、功能依赖(P = 0.04)、认知能力较低(P = 0.02)和抑郁症状(P = 0.03)的参与者将心血管结局置于跌倒损伤和药物症状之上的比例较低。

结论

面对相互竞争的结局时个体间的差异支持根据个体优先级进行个体化决策。在当前例子中,这可能意味着对某些个体放弃使用抗高血压药物或在血压降低方面做出妥协。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验