de Vlam Kurt, Lories Rik J U
University Hospitals Leuven, Division of Rheumatology, Herestraat 49, B-3000 Leuven, Belgium.
Curr Rheumatol Rep. 2008 Aug;10(4):297-302. doi: 10.1007/s11926-008-0048-z.
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necrosis factor agents have markedly improved articular and cutaneous signs and symptoms. The efficacy of tumor necrosis factor blockers also raised the bar for treatment goals in PsA. Remission may now be an attainable outcome in the treatment paradigm. At this time, specific tools to define PsA remission are not available. New assessments to define remission must be developed and incorporated into clinical trials and longitudinal registries.
银屑病关节炎(PsA)是一种与银屑病相关的慢性炎症性关节疾病,可导致关节畸形和残疾。PsA临床缓解和治愈的可能性较低。长期以来,PsA患者的治疗选择并不理想,但抗肿瘤坏死因子药物的引入显著改善了关节和皮肤的体征及症状。肿瘤坏死因子阻滞剂的疗效也提高了PsA治疗目标的标准。现在,缓解可能是治疗模式中可实现的结果。目前,尚无定义PsA缓解的特定工具。必须开发新的缓解评估方法并将其纳入临床试验和纵向登记处。