Ruiz-Rodríguez Ricardo, López Laura, Candelas Daniel, Pedraz Javier
Unidad de Dermatología, Clínica Ruber, Madrid, Spain.
J Drugs Dermatol. 2008 Jul;7(7):633-7.
Photodynamic therapy has been proved to be effective in skin rejuvenation.
To evaluate clinical efficacy and side effects of photodynamic therapy using topical 5-methyl aminolevulinate and red light for photorejuvenation.
A randomized, prospective, split-face comparison study of 10 white, adult patients with moderate photodamage, Fitzpatrick skin types 2 or 3, and no occurrence of actinic keratosis was performed. Three treatments using topical methyl aminolevulinate cream, applied for 1 hour on one half of the face and 3 hours on the other half before illumination with red light. A blinded investigator prior to treatment and 2 months after the third treatment evaluated each side of the subject's faces.
A moderate improvement in fine lines, tactile roughness, and skin tightness was observed in most of the patients, mostly on the 3-hour time side. There were no changes in mottled pigmentation or telangiectasias. Side effects were observed in all subjects (erythema, edema, scaling) mainly in the 3-hour incubation time side.
The small number of patients and the lack of placebo group.
Methyl aminolevulinic-photodynamic therapy with red light can improve fine lines, tactile roughness and skin tightness in patients with moderate photoaging and no occurrence of actinic keratosis.
光动力疗法已被证明在皮肤年轻化方面有效。
评估外用5-甲基氨基酮戊酸和红光进行光动力疗法改善皮肤外观的临床疗效和副作用。
对10名患有中度光损伤、Fitzpatrick皮肤类型为2或3且未发生光化性角化病的成年白人患者进行了一项随机、前瞻性、半脸对照研究。使用外用甲基氨基酮戊酸乳膏进行三次治疗，在红光照射前，一半脸涂抹1小时，另一半脸涂抹3小时。一名盲法研究者在治疗前和第三次治疗后2个月对受试者的每一侧面部进行评估。
大多数患者在细纹、触觉粗糙度和皮肤紧致度方面有中度改善，主要出现在3小时涂抹一侧。斑驳色素沉着或毛细血管扩张无变化。所有受试者均出现副作用（红斑、水肿、脱屑），主要出现在3小时孵育时间一侧。
患者数量少且缺乏安慰剂组。
甲基氨基酮戊酸-红光光动力疗法可改善中度光老化且未发生光化性角化病患者的细纹、触觉粗糙度和皮肤紧致度。
