Department of Dermatology, State University of New York, Downstate Health Sciences University, 450 Clarkson Ave, Box 46, Brooklyn, NY, USA.
Arch Dermatol Res. 2020 Oct;312(8):567-573. doi: 10.1007/s00403-020-02038-5. Epub 2020 Feb 14.
Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or reverse, effects of sun damage on the skin. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the body, has enormous potential to bind water which allows the skin to retain moisture and maintain elasticity. Topical application of HA has been found to produce anti-wrinkle effects. We conducted a pilot case series evaluating the safety and efficacy of a commercially available 2% 5-aminolevulinic acid (ALA) gel with hyaluronic acid (ALA-HA) and light-emitting diode-red light (LED-RL) for facial rejuvenation as determined by clinical assessments and digital skin analysis of rhytides, pore size, and erythema. All patients noted improvement of their skin and experienced minimal pain during PDT. Evaluation by dermatologists demonstrated significant improvement in overall skin appearance. Digital analysis of photographs revealed improvement of skin spots, wrinkles, pores, texture, UV spots, brown spots, red areas, and porphyrins. Our findings demonstrated safety and efficacy of this novel preparation of photodynamic gel with HA and subsequent activation with LED-RL.
光动力疗法（PDT）是一种成熟的非侵入性治疗方法，已显示出改善细纹、色素沉着不均和其他光损伤迹象等理想效果。许多患者希望减少或逆转阳光对皮肤造成的损伤。透明质酸（HA）是一种天然存在于体内的糖胺聚糖，具有巨大的结合水分的潜力，使皮肤保持水分并维持弹性。已经发现局部应用 HA 具有抗皱效果。我们进行了一项试点病例系列研究，评估了一种市售的 2% 5-氨基酮戊酸（ALA）凝胶与透明质酸（ALA-HA）和发光二极管-红光（LED-RL）联合用于面部年轻化的安全性和疗效，通过临床评估和数字皮肤分析皱纹、毛孔大小和红斑来确定。所有患者均注意到皮肤改善，并且在 PDT 期间仅感到轻微疼痛。皮肤科医生的评估表明，整体皮肤外观有显著改善。照片的数字分析显示皮肤斑点、皱纹、毛孔、纹理、UV 斑点、棕色斑点、红色区域和卟啉的改善。我们的研究结果表明，这种新型含 HA 的光动力凝胶及其随后与 LED-RL 联合应用具有安全性和有效性。
