Middleton John R
Department of Veterinary Medicine and Surgery, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA.
Expert Rev Vaccines. 2008 Aug;7(6):805-15. doi: 10.1586/14760584.7.6.805.
Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in humans and animals, as well as mastitis in dairy cattle. Methicillin-resistant S. aureus is increasingly recognized as a cause of staphylococcal infection and, therefore, immunotherapeutics have received new interest in both human and veterinary medicine. Vaccines aimed at preventing S. aureus infection in humans and mastitis in dairy cattle have been studied for many years. While some formulations have shown promise in ameliorating clinical disease, few, if any, of the S. aureus vaccines developed have adequately prevented new infection. The antigens targeted by S. aureus vaccines and potential reasons for the lack of success of vaccination against S. aureus are reviewed in this article.
金黄色葡萄球菌是人和动物医院感染及社区获得性感染的重要病因，也是奶牛乳腺炎的病因。耐甲氧西林金黄色葡萄球菌越来越被认为是葡萄球菌感染的病因，因此，免疫疗法在人类和兽医学中都受到了新的关注。针对预防人类金黄色葡萄球菌感染和奶牛乳腺炎的疫苗已经研究多年。虽然一些制剂在改善临床疾病方面显示出了前景，但开发的金黄色葡萄球菌疫苗中，几乎没有（如果有的话）能够充分预防新感染。本文综述了金黄色葡萄球菌疫苗所针对的抗原以及金黄色葡萄球菌疫苗接种失败的潜在原因。
