Abdullah Siraj Saadaldin, Pialat Jean Baptiste, Wiart Marlene, Duboeuf François, Mabrut Jean-Yves, Bancel Brigitte, Rode Agnès, Ducerf Christian, Baulieux Jacques, Berthezene Yves
Department of General Surgery and Liver Transplantation, La Croix Rousse Teaching Hospital, Lyon, France.
J Magn Reson Imaging. 2008 Aug;28(2):390-5. doi: 10.1002/jmri.21429.
To characterize and compare hepatocellular carcinoma and liver metastases of colorectal metastatic cancer (CMC) by means of quantitative liver perfusion MRI.
Liver perfusion was assessed in 26 HCC and CMC patients (50 nodules) by means of contrast-enhanced MRI. Six perfusion parameters-hepatic perfusion index (HPI), mean transit time (MTT), distribution volume (DV), total blood flow (F(T)), arterial blood flow (F(A)), and portal blood flow (F(P))-were calculated in tumor nodules and the adjacent hepatic parenchyma.
The values of F(T), F(A), F(P), and DV were significantly higher in the HCC than in the CMC group, whereas MTT was significantly higher in the CMC group. There was no significant difference in HPI. Arterial blood flow was higher than portal blood flow in the CMC group, while portal blood flow was slightly higher than arterial blood flow in the HCC group.
The present work describes the use of dynamic MRI to quantitatively assess liver perfusion, which in the future may help studying liver cancers on the basis of their microvascular characteristics.
通过定量肝脏灌注磁共振成像（MRI）对肝细胞癌（HCC）和结直肠癌肝转移癌（CMC）进行特征描述和比较。
通过对比增强MRI对26例HCC和CMC患者（50个结节）的肝脏灌注进行评估。在肿瘤结节及其相邻肝实质中计算六个灌注参数——肝灌注指数（HPI）、平均通过时间（MTT）、分布容积（DV）、总血流量（F(T)）、动脉血流量（F(A)）和门静脉血流量（F(P)）。
HCC组的F(T)、F(A)、F(P)和DV值显著高于CMC组，而CMC组的MTT显著更高。HPI无显著差异。CMC组的动脉血流量高于门静脉血流量，而HCC组门静脉血流量略高于动脉血流量。
本研究描述了使用动态MRI定量评估肝脏灌注，这在未来可能有助于根据肝癌的微血管特征对其进行研究。
