Turk J Med Sci. 2014;44(2):193-6. doi: 10.3906/sag-1303-27.
To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC).
Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples.
A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma.
CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.
评估 CT 灌注成像在肝细胞癌（HCC）患者中的作用。
对 17 例经活检证实的新发 HCC 患者（9 名男性，8 名女性）进行 256 排螺旋 CT 检查。在正常肝实质和 HCC 样本中计算血流（BF）、血容量（BV）、动脉灌注（AP）、门脉灌注（PP）和肝灌注指数（HPI）的灌注参数。
从 CT 灌注图像中评估了总共 21 个经组织学证实的 HCC 病变。HCC 病变中的 BF、BV、AP 和 HPI 值明显高于（P<0.05）正常肝实质，而 HCC 相对于肝实质的 PP 值明显较低（P<0.05）。
CT 灌注成像能够评估 HCC 的肿瘤评估、特征和新生血管形成。
