Radiology, Case Western Reserve University, Cleveland, OH, United States.
Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Sci Rep. 2018 Mar 21;8(1):4990. doi: 10.1038/s41598-018-20726-1.
We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48-72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student's t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
我们描述了使用自由呼吸、3D 螺旋 GRAPPA 基定量灌注 MRI 来描绘肿瘤性肝脏肿块的多机构经验。45 名患者（年龄：48-72 岁）在美国克利夫兰大学医院和中国上海中山医院的 3T（T）MRI 上前瞻性招募，在 1.5T MRI 上进行对比增强容积 T1 加权成像采集，并使用双输入单室模型得出病变和正常实质的动脉分数（AF）、分布容积（DV）和平均通过时间（MTT）。使用双尾学生 t 检验比较测量值，并对多次比较测试应用 Bonferroni 校正。评估了 28 例肝细胞癌（HCC）和 17 例转移性病变。在两个中心，正常肝实质和肿瘤肿块的灌注参数无显著差异（AF 的 p=0.62，DV 的 p=0.015，HCC 的 MTT 的 p=0.42，AF 的 p=0.13，DV 的 p=0.97，转移瘤的 MTT 的 p=0.78）。转移瘤的 AF、DV 和 MTT 与正常肝实质相比，HCC 的 AF 和 DV 有统计学显著差异（p<0.005/9=0.0055）。转移瘤的 MTT 与肝细胞癌相比有统计学显著差异（p<0.001*10-5）。总之，3D 螺旋-GRAPPA 实现的定量自由呼吸灌注 MRI 检查提供了强大的灌注参数。
