Miraux Sylvain, Massot Philippe, Ribot Emeline J, Franconi Jean-Michel, Thiaudiere Eric
Magnetic Resonance Center, UMR 5536 CNRS-Victor Segalen University of Bordeaux 2, Bordeaux, France.
J Magn Reson Imaging. 2008 Aug;28(2):497-503. doi: 10.1002/jmri.21449.
To examine the ability of TrueFISP imaging for evaluating tumor size in mouse brain at high field.
Brains of healthy and glioma-implanted nude mice were imaged at 4.7T and 9.4T. 3D imaging was performed with TrueFISP and T2w-RARE. Radiofrequency pulses with alternating phase and the sum-of-squares reconstruction method were used in TrueFISP imaging. The contrast-to-noise ratio (CNR) was evaluated in healthy and in tumoral brain regions.
Banding artifact was correctly suppressed in TrueFISP images thanks to the method used. The signal-to-noise ratio (SNR) and CNR were comparable in TrueFISP and T2w-RARE images at 4.7T, but acquisition was around 4 times shorter with TrueFISP. Tumor was well detected at 4.7T with TrueFISP, but CNR between tumor and healthy tissue was low at 9.4T.
TrueFISP is efficient and fast to perform brain imaging at 4.7T. Multiple TrueFISP acquisitions with phase-cycled radiofrequency (RF) pulses and sum-of-squares reconstruction allow suppression of banding artifact. Tumoral regions were well detected and the method allows longitudinal studies of tumor growth.
研究TrueFISP成像在高场强下评估小鼠脑肿瘤大小的能力。
对健康裸鼠和植入胶质瘤的裸鼠大脑在4.7T和9.4T场强下进行成像。使用TrueFISP和T2w-RARE序列进行三维成像。TrueFISP成像采用具有交替相位的射频脉冲和平方和重建方法。在健康脑区和肿瘤脑区评估对比噪声比（CNR）。
由于所采用的方法，TrueFISP图像中的带状伪影得到了正确抑制。在4.7T时，TrueFISP图像和T2w-RARE图像的信噪比（SNR）和CNR相当，但TrueFISP的采集时间缩短了约4倍。在4.7T时，TrueFISP能够很好地检测到肿瘤，但在9.4T时肿瘤与健康组织之间的CNR较低。
TrueFISP在4.7T场强下进行脑成像高效且快速。采用相位循环射频（RF）脉冲和平方和重建的多次TrueFISP采集可抑制带状伪影。肿瘤区域能够被很好地检测到，该方法可用于肿瘤生长的纵向研究。
