Santos M, Robledo M, Echezarreta G, Rivas C, Santón A, Benítez J
Departamento de Genética, Fundación Jiménez Díaz, Madrid.
Sangre (Barc). 1991 Apr;36(2):113-6.
Gene rearrangement analysis has been performed in 23 patients with T-cell lymphoproliferative diseases: 4 cases with T-gamma lymphocytosis, one case of a Sezary's syndrome, one case of T-cell angioimmunoblastic lymphoma, two cases of T-cell lymphoepitheloid lymphoma, 11 patients with T-cell pleomorphic lymphoma, 3 cases of large anaplastic T-cell lymphoma and one case of T-cell lymphoblastic lymphoma. Rearranged banding patterns have been observed for at least one of the T-cell receptors (TCR) in 19 of the cases, and germ line configuration of the TCR and Ig genes in the other four. Likewise, both Ig and TCR rearrangements have been observed in three cases (one case of T-cell pleomorphic lymphoma, one case of large anaplastic T-cell lymphoma and one case of T-cell lymphoblastic lymphoma). Molecular genetic techniques have been used in order to direct monoclonal proliferations of T cell in the tumoral tissues, to determine the T- or B-cell lineage of the neoplasia and also to outline the molecular characteristics of each group that constitutes the complex classification of T-cell malignancies.
对23例T细胞淋巴增殖性疾病患者进行了基因重排分析：4例Tγ淋巴细胞增多症、1例Sezary综合征、1例T细胞血管免疫母细胞性淋巴瘤、2例T细胞淋巴上皮样淋巴瘤、11例T细胞多形性淋巴瘤、3例大细胞间变性T细胞淋巴瘤和1例T细胞淋巴母细胞淋巴瘤。19例病例中至少观察到一种T细胞受体（TCR）的重排条带模式，另外4例为TCR和Ig基因的种系构型。同样，在3例病例中观察到Ig和TCR重排（1例T细胞多形性淋巴瘤、1例大细胞间变性T细胞淋巴瘤和1例T细胞淋巴母细胞淋巴瘤）。分子遗传学技术已被用于指导肿瘤组织中T细胞的单克隆增殖，确定肿瘤的T细胞或B细胞谱系，并勾勒构成T细胞恶性肿瘤复杂分类的每组的分子特征。
