Beacher F, Daly E, Simmons A, Prasher V, Morris R, Robinson C, Lovestone S, Murphy K, Murphy D G M
Institute of Psychiatry, King's College, London, UK.
Psychol Med. 2009 Apr;39(4):675-84. doi: 10.1017/S0033291708004054. Epub 2008 Jul 30.
Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD.
We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD.
DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals without AD, and 75% and 80% respectively of DS individuals with AD.
DS individuals with AD have significant medial temporal and striatal volume reductions, and these may provide markers of clinical AD.
唐氏综合征（DS）患者患阿尔茨海默病（AD）的风险很高。然而，很少有研究调查患有AD的DS个体的脑解剖结构。
我们通过容积磁共振成像（MRI）测量，比较了患有和未患有AD的DS个体的全脑解剖结构。我们还研究了容积差异是否能根据AD状态可靠地对DS个体进行分类。我们使用容积MRI和手动追踪来检查19名患有AD的DS成年个体和39名未患有AD的DS成年个体的脑区解剖结构。
与未患有AD的DS个体相比，患有AD的DS个体双侧海马体、尾状核、右侧杏仁核和壳核的校正体积明显更小，而左侧外周脑脊液（CSF）的校正体积明显更大。海马体和尾状核的体积分别正确地将92%的未患有AD的DS个体和75%的患有AD的DS个体分类，以及分别将92%的未患有AD的DS个体和80%的患有AD的DS个体分类。
患有AD的DS个体的内侧颞叶和纹状体体积显著减小，这些可能是临床AD的标志物。
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