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对患有和未患痴呆症的唐氏综合征患者的功能性神经影像学综述。

A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia.

作者信息

Deinde Funmi, Kotecha Jay, Lau Lilian Suh Lih, Bhattacharyya Sagnik, Velayudhan Latha

机构信息

Department of Psychological Medicine, South London and Maudsley NHS Foundation Trust, London, United Kingdom.

Cardiff University School of Medicine, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.

出版信息

Dement Geriatr Cogn Dis Extra. 2021 Dec 27;11(3):324-332. doi: 10.1159/000520880. eCollection 2021 Sep-Dec.

DOI:10.1159/000520880
PMID:35111192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8787537/
Abstract

BACKGROUND

Individuals with Down syndrome (DS) are at high risk of dementia which is difficult to diagnose in DS. Neuroimaging has been identified as a potential tool to aid diagnosis by detecting changes in brain function. We carried out a review comparing functional neuroimaging in DS individuals with and without dementia.

SUMMARY

A literature search was conducted using PubMed to identify relevant studies. In DS subjects with dementia, fluorodeoxyglucose-positron emission tomography (PET) studies showed glucose hypometabolism particularly in the parietal and/or temporal regions whilst magnetic resonance spectroscopy studies showed increased myoinositol and decreased N-acetylaspartate. Ligand-based PET studies revealed significant Pittsburgh compound B binding in DS subjects over the age of 40, particularly if they had dementia.

KEY MESSAGES

Neuroimaging may aid the early detection of dementia in DS; however, further longitudinal studies are required.

摘要

背景

唐氏综合征（DS）患者患痴呆症的风险很高，而DS患者的痴呆症难以诊断。神经影像学已被确定为一种通过检测脑功能变化来辅助诊断的潜在工具。我们进行了一项综述，比较了患有和未患有痴呆症的DS患者的功能神经影像学。

总结

使用PubMed进行文献检索以确定相关研究。在患有痴呆症的DS受试者中，氟脱氧葡萄糖正电子发射断层扫描（PET）研究显示葡萄糖代谢减低，尤其是在顶叶和/或颞叶区域，而磁共振波谱研究显示肌醇增加和N-乙酰天门冬氨酸减少。基于配体的PET研究显示，40岁以上的DS受试者中匹兹堡化合物B有显著结合，尤其是那些患有痴呆症的受试者。

关键信息

神经影像学可能有助于早期发现DS患者的痴呆症；然而，还需要进一步的纵向研究。

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本文引用的文献

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Alzheimers Dement (Amst). 2019 Nov 25;11:654-658. doi: 10.1016/j.dadm.2019.04.006. eCollection 2019 Dec.
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Neuropathological correlates of amyloid PET imaging in Down syndrome.唐氏综合征淀粉样蛋白 PET 成像的神经病理学相关性。
Dev Neurobiol. 2019 Jul;79(7):750-766. doi: 10.1002/dneu.22713. Epub 2019 Aug 17.
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Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.唐氏综合征和阿尔茨海默病神经病理学对默认模式连接的差异影响。
Hum Brain Mapp. 2019 Oct 15;40(15):4551-4563. doi: 10.1002/hbm.24720. Epub 2019 Jul 26.
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Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis.唐氏综合征中的代谢和血管成像生物标志物为脑老化和阿尔茨海默病发病机制提供了独特见解。
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5
Down syndrome is accompanied by significantly reduced cortical grey-white matter tissue contrast.唐氏综合征伴有明显的皮质灰质-白质组织对比度降低。
Hum Brain Mapp. 2018 Oct;39(10):4043-4054. doi: 10.1002/hbm.24230. Epub 2018 Jun 8.
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Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome.唐氏综合征患者的淀粉样蛋白-β负荷增加，出现类似阿尔茨海默病的代谢低下模式。
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