Davidson K M, Tyrer P, Tata P, Cooke D, Gumley A, Ford I, Walker A, Bezlyak V, Seivewright H, Robertson H, Crawford M J
Faculty of Medicine, University of Glasgow, Gartnavel Royal Hospital, Glasgow, UK.
Psychol Med. 2009 Apr;39(4):569-77. doi: 10.1017/S0033291708004066. Epub 2008 Jul 30.
Little information exists on treatment effectiveness in antisocial personality disorder (ASPD). We investigated the feasibility and effectiveness of carrying out a randomized controlled trial of cognitive behaviour therapy (CBT) in men with ASPD who were aggressive.
This was an exploratory two-centre, randomized controlled trial in a community setting. Fifty-two adult men with a diagnosis of ASPD, with acts of aggression in the 6 months prior to the study, were randomized to either treatment as usual (TAU) plus CBT, or usual treatment alone. Change over 12 months of follow-up was assessed in the occurrence of any act of aggression and also in terms of alcohol misuse, mental state, beliefs and social functioning.
The follow-up rate was 79%. At 12 months, both groups reported a decrease in the occurrence of any acts of verbal or physical aggression. Trends in the data, in favour of CBT, were noted for problematic drinking, social functioning and beliefs about others.
CBT did not improve outcomes more than usual treatment for men with ASPD who are aggressive and living in the community in this exploratory study. However, the data suggest that a larger study is required to fully assess the effectiveness of CBT in reducing aggression, alcohol misuse and improving social functioning and view of others. It is feasible to carry out a rigorous randomized controlled trial in this group.
关于反社会人格障碍(ASPD)治疗效果的信息较少。我们调查了对有攻击行为的ASPD男性进行认知行为疗法(CBT)随机对照试验的可行性和有效性。
这是一项在社区环境中进行的探索性双中心随机对照试验。52名被诊断为ASPD且在研究前6个月有攻击行为的成年男性被随机分为常规治疗(TAU)加CBT组或仅接受常规治疗组。在12个月的随访期间,评估攻击行为的发生情况以及酒精滥用、精神状态、信念和社会功能方面的变化。
随访率为79%。在12个月时,两组报告的言语或身体攻击行为发生率均有所下降。在问题饮酒、社会功能以及对他人的信念方面,数据显示出有利于CBT的趋势。
在这项探索性研究中,对于有攻击行为且生活在社区中的ASPD男性,CBT并未比常规治疗更能改善治疗效果。然而,数据表明需要进行更大规模的研究,以全面评估CBT在减少攻击行为、酒精滥用以及改善社会功能和对他人看法方面的有效性。在该群体中进行严格的随机对照试验是可行的。