将钙与β-淀粉样蛋白及阿尔茨海默病联系起来。
Linking calcium to Abeta and Alzheimer's disease.
作者信息
Green Kim N, LaFerla Frank M
机构信息
Department of Neurobiology and Behavior and Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA 92697-4545, USA.
出版信息
Neuron. 2008 Jul 31;59(2):190-4. doi: 10.1016/j.neuron.2008.07.013.
Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.
最近的研究进展表明钙调节异常在阿尔茨海默病的发病机制中起关键作用。一种名为CALHM1的新型钙传导通道与该疾病存在基因关联，并调节β淀粉样蛋白的产生。钙稳态在淀粉样斑块附近的树突棘中也被证明受到干扰。最后，新的研究阐明了早老素调节钙信号传导的作用，包括对SERCA2b的影响和IP3受体的门控作用，并导致β淀粉样蛋白的产生。
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