Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.
Adv Neurobiol. 2023;33:287-304. doi: 10.1007/978-3-031-34229-5_11.
Ryanodine receptors (RyRs) are Ca release channels located in the endoplasmic reticulum membrane. Presynaptic RyRs play important roles in neurotransmitter release and synaptic plasticity. Recent studies suggest that the proper function of presynaptic RyRs relies on several regulatory proteins, including aryl hydrocarbon receptor-interacting protein, calstabins, and presenilins. Dysfunctions of these regulatory proteins can greatly impact neurotransmitter release and synaptic plasticity by altering the function or expression of RyRs. This chapter aims to describe the interaction between these proteins and RyRs, elucidating their crucial role in regulating synaptic function.
Ryanodine 受体 (RyRs) 是位于内质网膜上的 Ca2+释放通道。突触前 RyRs 在神经递质释放和突触可塑性中发挥重要作用。最近的研究表明，突触前 RyRs 的正常功能依赖于几种调节蛋白，包括芳香烃受体相互作用蛋白、钙结合蛋白和早老素。这些调节蛋白的功能障碍可通过改变 RyRs 的功能或表达来极大地影响神经递质释放和突触可塑性。本章旨在描述这些蛋白与 RyRs 之间的相互作用，阐明它们在调节突触功能中的关键作用。
