Ferbert A, Busse D, Thron A
Department of Neurology, Klinikum Rheinisch-Westfählische Technische Hochschule, Aachen, Germany.
Stroke. 1991 Aug;22(8):1010-4. doi: 10.1161/01.str.22.8.1010.
By means of magnetic resonance imaging we investigated a total of 45 patients suffering from classic migraine; 25 patients had been treated in our department for classic migraine over the past 2 years (group A), and 20 other patients investigated between 1976 and 1984 were reexamined for this study (group B). Thirty-two age- and roughly sex-matched healthy volunteers underwent magnetic resonance imaging and served as controls (group C). There was a trend for patients with classic migraine to have more subcortical patchy lesions on T2-weighted magnetic resonance imaging. In a comparison of our control subjects and patients with a history of greater than 20 attacks of classic migraine taken from groups A and B, this difference in number of lesions was significant (p = 0.02). The results suggest that patchy lesions in patients with classic migraine should be interpreted with particular caution before diagnosing a demyelinating disease since the lesions could be ischemic in origin.
通过磁共振成像，我们共对45例典型偏头痛患者进行了研究；其中25例患者在过去两年内在我科接受过典型偏头痛治疗（A组），另外20例于1976年至1984年间接受过检查的患者为本次研究接受复查（B组）。32名年龄及性别大致匹配的健康志愿者接受磁共振成像检查并作为对照（C组）。典型偏头痛患者在T2加权磁共振成像上有更多皮质下斑片状病变的趋势。在将我们的对照受试者与A组和B组中发作次数超过20次的典型偏头痛患者进行比较时，病变数量的差异具有统计学意义（p = 0.02）。结果表明，在诊断脱髓鞘疾病之前，对于典型偏头痛患者的斑片状病变应格外谨慎地进行解读，因为这些病变可能源于缺血。
