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[乳腺分泌细胞细胞骨架的结构组织]

[The structural organization of the cytoskeleton of the mammary secretory cells].

作者信息

Pavlenko I N, Popov S M

出版信息

Tsitologiia. 1991;33(1):3-7.

PMID:1866792
Abstract

A study was made of the arrangement and specialties of distribution in the mammary secretory cells of albino mice of the following cytoskeleton ultrastructures: microtubules (MT), organization centres (MTOC), microfilaments (MF) and intermediate filaments (IF). During the last period of pregnancy and at different stages of lactation, for the alveolar epithelium the presence of a single material centrioles (CN) was shown in the region of the apical surface near dense intercellular contact. During pregnancy and especially at the beginning of lactation (1-2 days) the relatively large density of the MT was observed in both the cytoplasm of the secretory cells and the region near the CN. On the most hard days of lactation (10 day) the lowering of the number of all the observed structures was held in the majority of the cells. The MT was not observed near the CN. It appeared that the elimination of the MTOC activity during the most hard time of lactation is related to the decrease in the numbers of MT, MF and IF. The pattern of cytoskeleton reorganization, associated with the development of the functional activity of the observed cells, enables us to suggest a cooperative contribution of its base components in the formation of the secretory surface and in the carrying out of exocytosis.

摘要

对以下细胞骨架超微结构在白化小鼠乳腺分泌细胞中的分布排列及特性进行了研究

微管(MT)、组织中心(MTOC)、微丝(MF)和中间丝(IF)。在妊娠后期及泌乳的不同阶段,对于肺泡上皮,在靠近紧密细胞间接触的顶表面区域显示存在单个物质中心粒(CN)。在妊娠期间,尤其是泌乳初期(1 - 2天),在分泌细胞的细胞质以及CN附近区域观察到MT的密度相对较高。在泌乳最艰难的日子(第10天),大多数细胞中所有观察到的结构数量都有所减少。在CN附近未观察到MT。似乎在泌乳最艰难时期MTOC活性的消除与MT、MF和IF数量的减少有关。与所观察细胞功能活性发展相关的细胞骨架重组模式,使我们能够推测其基本成分在分泌表面形成及胞吐作用执行过程中的协同作用。

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Tsitologiia. 1991;33(1):3-7.
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