Davicino Roberto, Martinez Carolina, Mattar M Aída, Casali Yolanda, Correa Silvia G, Aragon Leslie, Saidman Elbio Antonio, Messina German, Micalizzi Blas
Department of Biochemistry and Biological Sciences, Microbiology Area, Faculty Chemistry, Biochemistry and Pharmacy, National University of San Luis, Chacabuco and Pedernera, San Luis, Argentine.
Immunopharmacol Immunotoxicol. 2008;30(3):489-501. doi: 10.1080/08923970802135211.
Larrea divaricata is a plant widely used in folk medicine in Argentina. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species. Decoction increased the binding of zymosan-FITC and superoxide production. Cadmium decreased the superoxide production as well as malonate and barbital. Decoction decreased the release of hydrogen peroxide. Decoction increased the reduction of MTT but not when malonate and barbital were included. Together, decoction increased the expression of dectin-1 leading to increased superoxide production. It is possible that decoction increases the activity of peroxidase, and decreases the Cu, Zn-superoxide dismutase.
