Drobek-Słowik Monika, Karczewicz Danuta, Safrano Krzysztof
Z Kliniki Okulistyki Pomorskiej Akademii Medycznej w Szczecinie.
Klin Oczna. 2008;110(1-3):40-3.
To evaluate the relationship between cataract, past cataract surgery and age-related macular degeneration (AMD).
281 eyes with AMD diagnosed with fundus fluorescein angiography were included to the study and divided into two groups: with dry (208) and exudative (73) type of AMD. 149 eyes without AMD were controls. We performed ophthalmological examination and questionnaire. We collected data regarding past cataract surgery, exposition to the sun, using of sunglasses and other.
Eyes with AMD were more likely to have cataract and nuclear sclerosis than controls. History of cataract surgery was significantly more frequent in group with exudative AMD compared to controls. Cataract (OR = 1.93), nuclear sclerosis (OR = 3.84) and past cataract surgery (OR = 2.32) were associated with increased risk of age-related macular degeneration in multivariate analyses adjusted for age.
The concomitance of cataract (especially nuclear sclerosis) and age-related macular degeneration may support the theory of common pathogenesis of both pathologies. There is increased risk of exudative type of AMD in eyes after cataract surgery.
评估白内障、既往白内障手术与年龄相关性黄斑变性（AMD）之间的关系。
纳入281只经眼底荧光血管造影诊断为AMD的眼睛，分为两组：干性AMD（208只）和渗出性AMD（73只）。149只无AMD的眼睛作为对照。我们进行了眼科检查和问卷调查。收集了有关既往白内障手术、日晒、使用太阳镜等方面的数据。
与对照组相比，AMD患者的眼睛更易患白内障和核硬化。与对照组相比，渗出性AMD组的白内障手术史明显更常见。在调整年龄的多因素分析中，白内障（比值比[OR]=1.93）、核硬化（OR = 3.84）和既往白内障手术（OR = 2.32）与年龄相关性黄斑变性风险增加相关。
白内障（尤其是核硬化）与年龄相关性黄斑变性并存可能支持这两种疾病具有共同发病机制的理论。白内障手术后眼睛发生渗出性AMD的风险增加。
