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[医护人员乙型肝炎病毒意外无症状感染及HBV标志物检测]

[Accidental asymptomatic infections with hephatitis B virus and testing on HBV markers of healthcare personnel].

作者信息

Sacić Enes, Sacić Dzana

机构信息

Ju Dom zdravlja Kantona Sarajevo.

出版信息

Med Arh. 2008;62(2):102-3.

Abstract

Healthcare personnel is being highly exposed to the professional risk of Hephatitis B virus infection by accidental professional injuries, where direct contact with patients blood occurs. Number of researches indicate significance and role of accidental injuries, especially over injection needles, which is leading cause for professional HBV infections occurence. HBsAg has capability to provoke imune system if applied to a man, to HBs anti-bodies production achieving thus protection from Hephatitis B Virus. Recombinant vaccine against viruse Hephatitis B achieves high imunology protection. It is considered that appereance of anti-HBs titre >10 mlU/ml upon received three doses of vaccine provides reliable protection from HBV infection. Aim of the work is to prove rates of asymptomatic HBV infection amongst healthcare personnel and other employees in Sarajevo Healthcare Institution, and to research occurence and rate of anti-HBs titre at vaccinated Healthcare personnel in Sarajevo Healthcare Institution one month upon received third dose of vaccine. Out of 980 examinees 4, or 0.41%, had acute HBV infection within research period, 10 or 1.02% examinees had chronical accidental HBV infection, 18 or 1.83 % out of 980 examinees had previous asymptomatic HBV infection, as the consequence of accidental injury. Results of these researches indicated that 82.76 % or 96 healthcare workers has had reliable protection from HB virus infection one month upon third vaccine dose against HBV, since achieved titres where higher than 10 mlU/ml.

摘要

医护人员因意外职业伤害而高度暴露于感染乙型肝炎病毒的职业风险中,这种伤害会导致与患者血液直接接触。多项研究表明了意外伤害的重要性和作用,尤其是通过注射针头造成的伤害,这是职业性乙肝病毒感染发生的主要原因。如果将乙肝表面抗原(HBsAg)应用于人体,它有能力激发免疫系统产生乙肝表面抗体(HBs抗体),从而实现对乙型肝炎病毒的防护。重组乙型肝炎疫苗可提供高度的免疫保护。人们认为,接种三剂疫苗后抗-HBs滴度>10 mIU/ml可提供可靠的乙肝病毒感染防护。本研究的目的是证实萨拉热窝医疗机构的医护人员及其他员工中无症状乙肝病毒感染的发生率,并研究萨拉热窝医疗机构接种疫苗的医护人员在接种第三剂疫苗一个月后抗-HBs滴度的出现情况及水平。在980名受检者中,有4人(0.41%)在研究期间发生急性乙肝病毒感染,10人(1.02%)受检者发生慢性意外乙肝病毒感染,980名受检者中有18人(1.83%)因意外受伤曾有过无症状乙肝病毒感染。这些研究结果表明,82.76%(即96名医护人员)在接种第三剂乙肝疫苗一个月后获得了可靠的乙肝病毒感染防护,因为其抗-HBs滴度高于10 mIU/ml。

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