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吉兰-巴雷综合征中的双侧动眼神经麻痹

Bilateral oculomotor nerve palsy in Guillain-Barre syndrome.

作者信息

Burina Adnan, Sinanović Osman, Smajlović Dzevdet, Vidović Mirjana

机构信息

Clinic for neurology, University Clinical center of Tuzla.

出版信息

Med Arh. 2008;62(2):119-20.

Abstract

Guillain-Barre syndrome (GBS) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system. GBS is also called acute idiopathic polyradiculoneuritis. Cranial nerves are affected in over 50% of all cases, with the facial nerves being affected the most. Otherwise, oculomotor nerves affection is rare and might occur in about 10% of cases. In this case report we present 61 years old female with GBS (acute motor and sensory axonal neuropathy subtype) associated with bilateral oculomotor nerve palsy. At the admittance in the neurological status were flaccid paraplegia, tendon reflexes absent at legs and reduced at arms, sensory disturbances in a distal (stocking-glove) distribution and bilateral ptosis. The disease was diagnosed on clinical features, nerve conduction velocity test (NCV), electromyogram (EMG) and cerebrospinal fluid (CSF) tests. After treatment with intravenous immunoglobulins and physical treatment the patient improved. She was able to walk by her own, mild semiptosis remained and she had no paresthesia.

摘要

吉兰-巴雷综合征(GBS)是一种获得性免疫介导的周围神经系统炎性疾病。GBS也被称为急性特发性多发性神经根神经炎。超过50%的病例会累及脑神经,其中面神经受累最为常见。此外,动眼神经受累较为罕见,约10%的病例可能出现。在本病例报告中,我们介绍了一名61岁患有GBS(急性运动和感觉轴索性神经病亚型)并伴有双侧动眼神经麻痹的女性。入院时神经系统检查发现弛缓性截瘫,双下肢腱反射消失,双上肢腱反射减弱,呈远端(手套袜套样)感觉障碍以及双侧上睑下垂。该疾病通过临床特征、神经传导速度测试(NCV)、肌电图(EMG)和脑脊液(CSF)检查得以确诊。经过静脉注射免疫球蛋白治疗和物理治疗后,患者病情有所改善。她能够自行行走,仍有轻度上睑下垂,且无感觉异常。

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