Vorob'eva L I, Khodzhaev E Iu, Ponomareva G M
Prikl Biokhim Mikrobiol. 2008 Mar-Apr;44(2):176-80.
Wild-type and mutant (AB 1157 and K-12) strains of Escherichia coli were shown to synthesize the logarithmic growth phase, exometabolites reactivating UV-irradiated cells of producer strains. The exometabolites of the strain K-12 were of protein nature and had a molecular weight of no more than 10 kDa. The reactivating activity of these exometabolites was inversely related to bacterial survival and slightly increased under the influence of stress factors. The reactivating factor of Luteococcus casei had a cross-reactivating and protective effect on UV-irradiated cells of E. coli strain K-12. Due to activation of the reactivating factor after UV irradiation and heating, the cross-protective effect increased more than threefold. The reactivating effect remained unchanged under these conditions. The protein exometabolites of E. coli did not induce cross-stress response in L. casei.
已证明大肠杆菌的野生型和突变型（AB 1157和K - 12）菌株在对数生长期合成胞外代谢产物，这些胞外代谢产物可使产生菌株经紫外线照射的细胞恢复活性。K - 12菌株的胞外代谢产物具有蛋白质性质，分子量不超过10 kDa。这些胞外代谢产物的恢复活性与细菌存活率呈负相关，并且在应激因素的影响下略有增加。干酪乳杆菌的恢复因子对大肠杆菌K - 12菌株经紫外线照射的细胞具有交叉恢复活性和保护作用。由于紫外线照射和加热后恢复因子的激活，交叉保护作用增加了三倍多。在这些条件下，恢复作用保持不变。大肠杆菌的蛋白质胞外代谢产物不会在干酪乳杆菌中诱导交叉应激反应。
