Shaĭkhelislamova M V, Sitdikov F G, Sitdikova A A, Kuz'mina L Iu, Valeeva F V
Ontogenez. 2008 Mar-Apr;39(2):116-24.
A complex study of the functional state of the sympathoadrenal system and adrenal cortex in 10-15-year-old children of both sexes was carried out using the indices of daily excretion of adrenaline, noradrenaline, 17-ketosteroids, and 17-hydroxycorticosteroids. A synchronism in the functional activity of the mediator component of the sympathoadrenal system as well as of the androgenic and glucocorticoid functions of the adrenal cortex was observed with age and during pubertal development of children. At the same time, heterochronic maturation was observed in the sex groups: in girls at the age of 10 and 12 years and in boys at the age of 14-15 years. The changes of different direction and intensity in the excretion of the studied hormones and hormonal metabolites were observed in the sex and age groups. A sharp increase in the daily excretion of glucocorticoid metabolites accompanied by a considerable decrease in the age index of noradrenaline secretion was observed in 14- and 15-year-old boys from beginning to end of school year; in addition, an increase in the daily excretion of sex hormones was observed at the age of 15 years. In girls, these indices varied within the age range, which points to a more sophisticated neuroendocrine control of physiological functions in girls during puberty.
利用肾上腺素、去甲肾上腺素、17-酮类固醇和17-羟皮质类固醇的每日排泄指标，对10至15岁男女儿童的交感肾上腺系统和肾上腺皮质的功能状态进行了一项综合研究。随着年龄增长以及儿童青春期发育，观察到交感肾上腺系统介质成分的功能活动与肾上腺皮质雄激素和糖皮质激素功能之间存在同步性。同时，在不同性别组中观察到异时成熟现象：女孩在10岁和12岁时，男孩在14至15岁时。在不同性别和年龄组中，所研究激素及其代谢产物的排泄呈现出不同方向和强度的变化。在14至15岁男孩从学年开始到结束期间，观察到糖皮质激素代谢产物的每日排泄量急剧增加，同时去甲肾上腺素分泌的年龄指数大幅下降；此外，在15岁时观察到性激素的每日排泄量增加。在女孩中，这些指标在年龄范围内有所变化，这表明女孩在青春期生理功能的神经内分泌控制更为复杂。
