Hildrum Bjørn, Mykletun Arnstein, Holmen Jostein, Dahl Alv A
Department of Psychiatry, Namsos Hospital, N-7800 Namsos, Norway.
Br J Psychiatry. 2008 Aug;193(2):108-13. doi: 10.1192/bjp.bp.107.045013.
The long-term effect of anxiety and depression on blood pressure is unclear.
To examine the prospective association of anxiety and depression with change in blood pressure in a general population.
Data on 36 530 men and women aged 20-78 years participating in the Nord-Trøndelag Health Study (HUNT) in Norway in 1984-86 were re-examined 11 years later.
A high symptom level of anxiety and depression at baseline predicted low systolic blood pressure (< 10th percentile) at follow-up (OR=1.30, 95% CI 1.08-1.57) when those with low systolic blood pressure at baseline were excluded. Change in symptom level of anxiety and depression between baseline and follow-up was inversely associated with change in systolic blood pressure. For diastolic blood pressure, the findings were weaker or non-significant.
Symptoms of anxiety and depression predicted lower blood pressure 11 years later.
焦虑和抑郁对血压的长期影响尚不清楚。
研究普通人群中焦虑和抑郁与血压变化之间的前瞻性关联。
对1984 - 1986年参与挪威北特伦德拉格健康研究(HUNT)的36530名年龄在20 - 78岁的男性和女性的数据在11年后进行重新分析。
排除基线收缩压较低者后,基线时焦虑和抑郁症状水平较高预示着随访时收缩压较低(低于第10百分位数)(比值比=1.30,95%置信区间1.08 - 1.57)。基线与随访之间焦虑和抑郁症状水平的变化与收缩压的变化呈负相关。对于舒张压,研究结果较弱或无统计学意义。
焦虑和抑郁症状预示着11年后血压较低。