Suwa T, Itakura C
Department of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan.
Avian Pathol. 1992 Sep;21(3):443-52. doi: 10.1080/03079459208418862.
The air sac of chicks inoculated with Chlamydia psittaci was examined ultrastructurally. The epithelial cells had minute chlamydial inclusion bodies consisting of a few reticulate bodies in the initial stages of infection. In the epithelial cells in the early and middle stage of infection, small- to medium-sized chlamydial inclusion bodies were found in the cytoplasm adjacent to the Golgi apparatus and surrounded with many mitochondria. The cytoplasm having chlamydial inclusion bodies was rich in free ribosomes and rough endoplasmic reticulum. Chlamydial inclusion bodies in the epithelial cells in the late stages of infection were enlarged and contained many intermediate and elementary bodies. The cytoplasm of the involved epithelial cells had dilated endoplasmic reticulum, and swollen and degenerated mitochondria, and were poor in ribosomes and myelin figure-like structures. Subsequently, the epithelial cells were desquamated from the air sac wall. Macrophages and a few heterophils also were infiltrated into the intercellular spaces. Chlamydiae multiplied actively in the macrophages. It was concluded that airsacculitis was initiated with epithelial cell changes resulting from chlamydial multiplication.
对感染鹦鹉热衣原体的雏鸡气囊进行了超微结构检查。在感染初期，上皮细胞中有微小的衣原体包涵体，由一些网状体组成。在感染的早期和中期，上皮细胞中，在靠近高尔基体且被许多线粒体包围的细胞质中发现了中小型衣原体包涵体。含有衣原体包涵体的细胞质富含游离核糖体和粗面内质网。感染后期上皮细胞中的衣原体包涵体增大，含有许多中间体和原体。受累上皮细胞的细胞质内质网扩张，线粒体肿胀退变，核糖体和髓鞘样结构较少。随后，上皮细胞从气囊壁脱落。巨噬细胞和一些嗜异性粒细胞也浸润到细胞间隙。衣原体在巨噬细胞中活跃繁殖。得出的结论是，气囊炎始于衣原体繁殖导致的上皮细胞变化。
